A Rapid Three-Component MgI2-Mediated Synthesis of 3,3-Pyrollidinyl Spirooxindoles

作者:Helan Victoria; Mills Allie; Drewry David; Grant Daniel*
来源:Journal of Organic Chemistry, 2010, 75(19): 6693-6695.
DOI:10.1021/jo101077g

摘要

The rapid synthesis of 3,3-pyrrolidinyl-spirooxindole cores from readily available cyclopropyl spirooxindoles and commercially available aldehydes, amines, and sulfonamides is reported. This general procedure utilizes microwave heating to access a biologically privileged scaffold in an efficient route amenable to library population.

  • 出版日期2010-10-1