Association between the prevalence of obstructive sleep apnoea and the severity of keratoconus

作者：Naderan Mohammad; Rezagholizadeh Farzaneh; Zolfaghari Masoome; Naderan Morteza; Rajabi Mohammad Taher; Kamaleddin Mohammad Amin

来源：British Journal of Ophthalmology, 2015, 99(12): 1675-1679.

DOI：10.1136/bjophthalmol-2015-306665

Aim The purpose of this study was to determine the association between prevalence of obstructive sleep apnoea (USA) in patients with keratoconus (KC) and the severity of KC.
Methods Six-hundred and sixteen patients with KC and 616 patients without KC in the control group were enrolled in this prospective case-control study. Both groups were matched by age, gender, and body mass index (BMI). The Berlin Questionnaire was administered in both groups. Keratometric and topographic measurements of the KC eyes were recorded.
Results Seventy-six (12.3%) and 40 (6.5%) patients were identified as high risk for developing USA in KC and control groups, respectively (p<0.001). Family history of USA and BMI were the risk factors for USA in the KC group, while in the control group the only risk factor for USA was the patient's gender. Patients with KC with a high risk of USA had a significantly higher mean K, flat K, steep K (p<0.05), and a thinner corneal thickness (p<0.05). The severity of KC decreased in both USA groups except for the grade 4 of high risk group which was the second most frequent group after grade 1 (p=0.005).
Conclusions Our study revealed that patients with KC are at increased risk of developing USA, and patients with KC who are at higher risk of developing USA may have more severe KC.

• 出版日期2015-12