DIFFERENCES IN DOPAMINE D-2-LIKE RECEPTOR-MEDIATED G-PROTEIN ACTIVATION IN THE MEDIAL PREFRONTAL CORTEX AFTER COCAINE

作者：Sun Wei Lun; Festa Eugene D; Jenab Shirzad; Quinones Jenab Vanya^*

来源：Ethnicity & Disease, 2010, 20(1): 88-91.

• Cocaine
• Dopamine
• G-protein
• Cortex

Introduction: Sexually dimorphic behavioral responses to cocaine have been linked to a difference in activation of dopamine receptors. Our study was conducted to determine whether dopamine D-2-like receptor-activated G-protein contributes to sex differences in response to cocaine in the medial prefrontal cortex (mPFC).
Method: In vitro functional autoradiography was performed using dopamine receptor D-2 agonist (quinpirole, 100 04) to stimulate [S-35]GTP gamma S binding in brain tissue sections from male and female Fischer rats treated with saline (1 mL/kg) or cocaine (20 mg/kg; i.p.).
Results: Overall, quinpirole increased G-protein activation in the caudate-putamen, nucleus accumbens, and frontal cortex in both sexes. Although saline-treated male rats had higher [S-35]GTP gamma S binding in the mPFC than their female counterparts, cocaine-treated females had higher [S-35]GTP gamma S binding in the mPFC than cocaine-treated males.
Conclusions: These data suggest that both intrinsic and actiyational effects of dopamine D-2-like receptor-mediated G-protein activation in the mPFC may contribute to the differences between males and females in their response to acute cocaine administration. (Ethn Dis. 2010;20[Suppl 1]:S1-88-S1-91)

• 出版日期2010