Asymmetric Hydrogenation of Aromatic Ketones Catalyzed by RuCl2[(S)-P-Phos]-[(S)-DAIPEN]

作者：Jiang He; Wang Jin Bo^*; Xiong Wei; Jia Yun; Qin Rui Xiang; Liu De Rong; Chen Hua

来源：Acta Physico - Chimica Sinica, 2010, 26(3): 675-678.

• Asymmetric hydrogenation
• Ruthenium-phosphine complex
• Chiral diamine
• Aromatic ketones

A ruthenium phosphine diamine complex RuCl2[(S)-P-Phos]-[(S)-DAIPEN] [P-Phos: 2,2',6,6'-tetramethoxy-4,4'-bis(diphenylphosphino)-3,3'-bipyridine, DAIPEN: 1,1'-di(4-anisyl)-2-iopropyl-1,2-ethylenediamine] for the asymmetric hydrogenation of aromatic ketones has been Studied. The influences of different bases. (CH3)(3)COK concentration, organic solvent, and molar ratio of substrate to catalyst on activity and enantioselectivity were investigated. Under the following optimum conditions: n(ketone):n(KOH):n(catalyst)=1000:20:1, p(H2)=2 MPa and T=30 degrees C the conversion of acetophenone and the enantioselectivity (ee) of S-1-phenylethanol was 100% and 88.5%, respectively. Additionally, the ee value of 2'-bromophenyl ethanol was 97.1%.

• 出版日期2010-3
• 单位重庆大学; 四川大学