ATM Mutations in Cancer: Therapeutic Implications

作者：Choi Michael^*; Kipps Thomas; Kurzrock Razelle

来源：Molecular Cancer Therapeutics, 2016, 15(8): 1781-1791.

DOI：10.1158/1535-7163.MCT-15-0945

Activation of checkpoint arrest and homologous DNA repair are necessary for maintenance of genomic integrity during DNA replication. Germ-line mutations of the ataxia telangiectasia mutated (ATM) gene result in the well-characterized ataxia telangiectasia syndrome, which manifests with an increased cancer predisposition, including a 20% to 30% lifetime risk of lymphoid, gastric, breast, central nervous system, skin, and other cancers. Somatic ATM mutations or deletions are commonly found in lymphoid malignancies, as well as a variety of solid tumors. Such mutations may result in chemotherapy resistance and adverse prognosis, but may also be exploited by existing or emerging targeted therapies that produce synthetic lethal states.

• 出版日期2016-8-1