Additive manufacturing techniques for the production of tissue engineering constructs

作者：Mota Carlos; Puppi Dario; Chiellini Federica; Chiellini Emo^*

来源：Journal of Tissue Engineering and Regenerative Medicine, 2015, 9(3): 174-190.

DOI：10.1002/term.1635

• additive manufacturing
• solid freeform fabrication
• tissue engineering
• regenerative medicine
• tissue and organ printing
• scaffold

Additive manufacturing' (AM) refers to a class of manufacturing processes based on the building of a solid object from three-dimensional (3D) model data by joining materials, usually layer upon layer. Among the vast array of techniques developed for the production of tissue-engineering (TE) scaffolds, AM techniques are gaining great interest for their suitability in achieving complex shapes and microstructures with a high degree of automation, good accuracy and reproducibility. In addition, the possibility of rapidly producing tissue-engineered constructs meeting patient's specific requirements, in terms of tissue defect size and geometry as well as autologous biological features, makes them a powerful way of enhancing clinical routine procedures. This paper gives an extensive overview of different AM techniques classes (i.e. stereolithography, selective laser sintering, 3D printing, melt-extrusion-based techniques, solution/slurry extrusion-based techniques, and tissue and organ printing) employed for the development of tissue-engineered constructs made of different materials (i.e. polymeric, ceramic and composite, alone or in combination with bioactive agents), by highlighting their principles and technological solutions.

• 出版日期2015-3