Association of single nucleotide polymorphism rs10757274 A/G with coronary heart disease in the presence and absence of diabetes in a Chinese population

作者：Li, Yuxi; Chen, Dafang; Zhang, Yan; Yi, Tieci; Weng, Haoyu; Gong, Yanjun; Li, Jianping^*; Huo, Yong

来源：International Journal of Clinical and Experimental Medicine, 2016, 9(11): 22387-22392.

• Coronary heart disease
• single nucleotide polymorphism
• 9p21
• rs10757274

Background: A recent genome wide association study in Chinese Han Population has implicated rs10757274 A/G polymorphism on chromosome 9p21.3 was associated with coronary heart disease (CHD), and diabetes may have a modifying role. In this study, we aimed to evaluate the association of the SNP with CHD in the presence and absence of type 2 diabetes mellitus (T2D) in a Chinese population. Methods and Results: SNP of rs10757274 at 9p21.3 locus was genotyped in 1,168 CHD patients and 294 controls, among which all cases were diagnosed through angiography. We compared subjects using a dominant model for the risk allele G; AG (n = 735), GG (n = 302) vs. AA (n = 425), multivariate liner regression was used with adjustment for age, sex, ethnicity, smoking status, alcohol intake, hypertension, hyperlipidemia and diabetes. In addition, we evaluated diabetes-specific genetic effect on CHD. There was a significant association between rs10757274 A/G polymorphism and CHD, both for AG (OR = 1.40, 95% CI: 1.03-1.91) and GG (OR = 2.48, 95% CI: 1.64-3.76) genotypes vs. AA genotype. While further diabetes-specific analysis showed different results between AG and GG vs. AA genotypes for the association of rs10757274 with CHD in the presence and absence of T2D. GG is associated with CHD in both with and without diabetes while AG is associated with CHD only in diabetes. Conclusions: The rs10757274 A/G polymorphism was associated with greater risk of CHD, and this association may be modified by diabetes status.

• 出版日期2016
• 单位北京大学