Activity of synthetic peptides against Chlamydia

作者：Donati Manuela; Cenacchi Giovanna; Biondi Roberta; Papa Valentina; Borel Nicole; Nepita Edoardo Vecchio; Magnino Simone; Pasquinelli Gianandrea; Levi Aurora; Franco Octavio L^*

来源：Biopolymers, 2017, 108(6): e23032.

DOI：10.1002/bip.23032

• antimicrobial
• chlamydia
• immunofluorescence
• peptides

The in vitro activity of six synthetic peptides against 36 strains of Chlamydia from different origins was investigated. Clavanin MO (CMO) proved to be the most active peptide, reducing the inclusion number of all Chlamydia strains from eight different species tested by 50% at 10 mu gmL(-1). Mastoparan L showed an equal activity against C. trachomatis, C. pneumoniae, C. suis, and C. muridarum, but did not exert any inhibitory effect against C. psittaci, C. pecorum, C. abortus, and C. avium even at 80 mu gmL(-1). These data suggest that CMO could be a promising compound in the prevention and treatment of chlamydial infections.

• 出版日期2017-11