Allergin-1 inhibits TLR2-mediated mast cell activation and suppresses dermatitis

作者：Tsurusaki Satoshi; Tahara Hanaoka Satoko^*; Shibagaki Shohei; Miyake Shota; Imai Masamichi; Shibayama Shiro; Kubo Masato; Shibuya Akira

来源：International Immunology, 2016, 28(12): 605-609.

DOI：10.1093/intimm/dxw046

• allergin-1
• dermatitis
• mast cell
• TLR2

TLR2 recognizes cell wall components of Staphylococcus aureus, which colonizes >90% of atopic eczematous skin lesions. The regulatory mechanisms of TLR2 signaling in the skin remain unclear. Allergin-1, an inhibitory immunoglobulin-like receptor containing an ITIM, is expressed on mast cells (MCs) and inhibits IgE-mediated anaphylaxis in mice. Here, we show that Allergin-1 inhibits TLR2-mediated activation of, and inflammatory cytokine production by, MCs in vitro. Compared with wild-type mice, Allergin-1-deficient mice showed enhanced ear swelling with enhanced collagen deposition and greater Ly6G(+) neutrophil recruitment after intra-dermal injection of Pam2CSK4 into pinnae. Using Mas-TRECK mice, which is an MC deletion system based on il4 enhancer elements, we also demonstrated that Allergin-1 on MCs is responsible for the Pam2CSK4-induced ear swelling. These results suggest that Allergin-1 on skin MCs suppresses TLR2-induced dermatitis.

• 出版日期2016-12