A New Cytotoxic Brominated Acetylenic Hydrocarbon from the Marine Sponge Haliclona sp with a Selective Effect against Human Breast Cancer

作者：Alarif Walied M; Abdel Lateff Ahmed^*; Al Lihaibi Sultan S; Ayyad Seif Eldin N; Badria Farid A

来源：Zeitschrift fur Naturforschung Section C-A Journal of Biosciences, 2013, 68(1-2): 70-75.

DOI：10.5560/ZNC.2013.68c0070

• Marine Sponge Haliclona sp.
• Acetylenic
• Brominated Fatty Acid

Three acetylenic brominated derivatives were isolated from a Red Sea sponge, Haliclona sp. One of them, 18-bromooctadeca-9(E),17(E)-dien-7,15-diynoic acid (3), is a known metabolite, and the other two are new compounds, (1E,5E,12E,19E)-1,22-dibromodocosa-1,5,12,19-tetraen-3,14,21-triyne (1) and methyl 18-bromooctadeca-9(E),17(E)-dien-7,15-diynoate (2) which was isolated for the first time as a natural metabolite. Structures of all compounds were determined based on extensive spectroscopic measurements [1D (H-1, C-13 and DEPT) and 2D (HSQC, HMBC and NOESY) NMR, MS, UV, and IR]. All compounds, except 3, were evaluated for their cytotoxicity employing four cancer cell lines, i.e. MCF-7 (human breast cancer), HepG2 (human hepatocellular carcinoma), WI-38 (skin carcinoma), and Vero (African green monkey kidney). Compounds 1 and 2 had potent selective antitumour activity towards MCF-7 cells with IC50, values of 32.5 and 50.8 mu m, respectively.

• 出版日期2013-2