alpha-thalassemia-associated hydrops fetalis: A rare cause of thyrotoxic cardiomyopathy

作者：Tumian Nor Rafeah; Wong Ming; Wong Chieh Lee^*

来源：Journal of Obstetrics and Gynaecology Research, 2015, 41(6): 967-970.

DOI：10.1111/jog.12648

• alpha-thalassemia
• hydrops fetalis
• hyperplacentosis
• hyperthyroidism
• cardiac failure in pregnancy

alpha degrees-thalassemia is a well-known cause of hydrops fetalis in South-East Asia and can be detected in utero. We report a very rare case of thyrotoxic cardiomyopathy associated with hyperplacentosis secondary to degrees-thalassemia-associated hydrops fetalis. A 22-year-old primigravida with microcytic anemia presented at 27 weeks' gestation with pre-eclampsia, hyperthyroidism and cardiac failure. Serum -human chorionic gonadotrophin was markedly elevated and abdominal ultrasound revealed severe hydropic features and enlarged placenta. Serum -human chorionic gonadotrophin, cardiac function and thyroid function tests normalized after she delivered a macerated stillbirth. Histopathology of the placenta showed hyperplacentosis. Blood DNA analysis revealed that both patient and husband have the degrees-thalassemia trait. This case illustrates a very atypical presentation of degrees-thalassemia-associated hydrops fetalis and the importance of early prenatal diagnosis of -thalassemia in women of relevant ethnic origin with microcytic anemia so that appropriate genetic counseling can be provided to reduce maternal morbidity and the incidence of hydrops fetalis.

• 出版日期2015-6