Urinary Kidney Injury Molecules in Children with Iron-Deficiency Anemia

作者：Gunes Ali^*; Ece Aydin; Aktar Fesih; Tan Ilhan; Soker Murat; Karabel Duran; Balik Hasan; Uluca Unal; Sen Velat; Yolbas Ilyas

来源：MEDICAL SCIENCE MONITOR, 2015, 21: 4023-4029.

DOI：10.12659/msm.896794

• Anemia, Iron-Deficiency
• Early Diagnosis
• Kidney Diseases

Background: The aim of this study was to investigate the urine levels of human kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), N-acetyl-beta-D-glucosaminidase (NAG), and liver-type fatty acid-binding protein (L-FABP) in children with iron-deficiency anemia (IDA).
Material/Methods: Thirty-five children with IDA and 32 matched healthy controls were recruited. We assessed complete blood count, serum iron, iron-binding capacity, ferritin, serum levels of urea, creatinine (Cr), sodium (Na), potassium (K), calcium (Ca), and glucose levels. Estimated glomerular filtration rate (eGFR) was calculated. Urinary NAG, NGAL, KIM-1, and L-FABP were measured and divided by urine creatinine for comparisons.
Results: There were no significant differences in serum urea, Cr, or eGFR between the IDA group and the control group (p>0.05, for all). IDA patients had significantly higher urine NGAL/Cr, L-FABP/Cr, KIM-1/Cr, and NAG/Cr compared with the control group (p<0.05). There were significant negative correlations between hemoglobin, hematocrit, red blood cell count, and urine NGAL/Cr, NAG/Cr, L-FABP/Cr, KIM-1/Cr levels (p<0.05).
Conclusions: Higher urinary kidney injury molecule levels in IDA patients suggest a possible subclinical renal injury in pediatric IDA patients whose renal functions and serum electrolytes were normal.

• 出版日期2015-12-24