Association of interleukin-10 polymorphisms and haplotypes with the risk of breast cancer in northern China

作者：Tian, Kun; Zhang, Ruiming; Wang, Xia^*

来源：International Journal of Clinical and Experimental Pathology, 2017, 10(6): 6989-6996.

• IL-10
• rs1800872
• rs1800871
• rs1800896
• polymorphism
• haplotype
• breast cancer

Many environmental and genetic factors are involved in the development of breast cancer. IL-10 is an immunoregulatory cytokine produced by Th2 cells, regulatory T cells, and monocytes/macrophages. We carried out a case-control study to assess the relationship of three SNPs (rs1800872, rs1800871 and rs1800896) in the promoter regions of IL-10 with the risk of breast cancer. A hospital based case-control study was implemented, including 312 patients with breast cancer and 312 control subjects. The genotyping of IL-10 rs1800872, rs1800871 and rs1800896 was implemented in a 384-well plate format on the sequenom MassARRAY platform. We observed that the homozygous AA genotype of rs1800896 was significantly associated with risk of breast cancer, when compared to the homozygous GG genotype, with an adjusted OR (and 95% CI) of 1.98 (1.12-3.49). The haplotype analysis showed linkage disequilibrium between rs1800872 and rs1800896 (D'=0.62, r(2)=0.10). The C-T-G (OR=0.76, 95% CI=0.59-0.98) haplotype revealed a reduced risk of breast cancer, while the A-T-A (OR=1.78, 95% CI=1.16-2.74) indicated an elevated risk of breast cancer in the Chinese population. In conclusion, the present study indicates that IL-10 rs1800896 polymorphism and A-T-A and C-T-G haplotypes could affect the risk of breast cancer.

• 出版日期2017
• 单位内蒙古医科大学