科研之友
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摘要
Background We previously showed that thermal injury depletes plasma vitamin E in pediatric burn patients however plasma changes may reflect immediate alterations in vitamin E nutriture Adipose tissue alpha tocopherol concentrations are generally accepted to reflect long term vitamin E status Objective To test the hypothesis that thermal injury depletes body stores of vitamin E alpha tocopherol concentrations were measured in adipose tissue samples Design Pediatric patients (n = 8) were followed up to 1 y after burn injury Surgically obtained samples were collected at various intervals and stored at -80 degrees C in a biorepository alpha and gamma Tocopherols cholesterol and triglycerides were measured in the same tissue aliquot Results During the first week after injury adipose tissue alpha tocopherol concentrations were within the expected normal range of 199 +/- 40 nmol/g adipose tissue but were substantially lower at weeks 2 and 3 (133 +/- 13 and 109 +/- 8 nmol/g adipose tissue respectively) Individual rates of decrease estimated by linear regression showed that adipose tissue alpha tocopherol decreased by an average of 6 1 +/- 0 6 nmol/g daily During the first month after injury adipose tissue triglyceride concentrations also decreased whereas no changes in cholesterol concentrations occurred Conclusions These data emphasize that the burn injury experienced by these pediatric patients altered their metabolism such that vitamin E status diminished during the month after injury Further studies are needed to evaluate the mechanism and consequences of the observed vitamin E depletion This trial was registered at clinicaltrials gov as NCT00675714 Am J Clin Nutr 2010 92 1378-84
- 出版日期2010-12
