Are Presynaptic Proteins Predisposed to Self-Assemble?

作者：Goldstein Ann Y N; Schwarz Thomas L^*

来源：Neuron, 2010, 66(5): 624-627.

DOI：10.1016/j.neuron.2010.05.021

Tight control of synapse formation ensures that neurons connect to appropriate targets. In this issue of Neuron, Klassen et al. identify ARL-8 GTPase as a regulator of presynaptic assembly. Without ARL-8, presynaptic material aggregates en route to its destination, suggesting that ARL-8 acts like a dispersant to prevent premature synaptic assembly in the axon.

• 出版日期2010-6-10