Ultrasonically-promoted synthesis of mandelic acid by phase transfer catalysis in an ionic liquid

作者：Qian Hua^*; Liu Dabin; Lv Chunxu

来源：Ultrasonics Sonochemistry, 2011, 18(5): 1035-1037.

DOI：10.1016/j.ultsonch.2010.12.009

• Mandelic acid
• Ultrasound
• Phase transfer catalyst
• Ionic liquid
• Synthesis

An efficient and facile process to synthesize mandelic acid through phase transfer catalysis (PTC; also phase transfer catalyst) using ultrasound in an ionic liquid has been developed. Mandelic acid was synthesized from benzaldehyde with chloroform in an 89.6% yield at 60 degrees C for 2 h by using tetrabutyl ammonium bromide (TBAB) as a phase transfer catalyst. Effects of different factors, such as frequency of ultrasound, reaction temperature, kinds of PTC and solvents had been investigated to obtain the optimum condition. It was observed that the ultrasonically promoted synthesis of mandelic acid by PTC in the ionic liquid exhibited significant enhancement in reaction yields under ambient conditions.

• 出版日期2011-9
• 单位南京理工大学