A Ce(III)-catalyzed expeditious multicomponent stereoselective synthesis of 3-mercapto-2(1H)-pyridinones

作者：Yadav Lal Dhar S^*; Kapoor Ritu

来源：Tetrahedron Letters, 2008, 49(33): 4840-4844.

DOI：10.1016/j.tetlet.2008.06.006

• multicomponent reaction
• Lewis acid
• chalcones
• 1,3-oxathiolan-5-one
• 3-mercapto-2(1H)-pyridinones
• stereoselective synthesis

A novel Ce(III)-catalyzed, convenient, expeditious, and chastereoselective synthesis of 3-mercapto-2(IH)-pyridinones via one-pot, [3+2+1] three-component coupling reactions of chalcones, 2-methyl-2-phenyl-1,3 -oxathiolan-5-one, and amines is reported. The synthesis involves sequential Michael addition, condensation, and ring transformation. Ambient temperature, operational simplicity, use of an environmentally clean catalyst, high yields, and diastereoselectivity are the key features of the present synthetic Protocol.

• 出版日期2008-8-11