ERR gamma Preserves Brown Fat Innate Thermogenic Activity

作者：Ahmadian Maryam; Liu Sihao; Reilly Shannon M; Hah Nasun; Fan Weiwei; Yoshihara Eiji; Jha Pooja; De Magalhaes Filho C Daniel; Jacinto Sandra; Gomez Andrew V; Dai Yang; Yu Ruth T; Liddle Christopher; Atkins Annette R; Auwerx Johan; Saltiel Alan R; Downes Michael^*; Evans Ronald M^*

来源：Cell Reports, 2018, 22(11): 2849-2859.

DOI：10.1016/j.celrep.2018.02.061

Brown adipose tissue (BAT) adaptively transfers energy from glucose and fat into heat by inducing a gene network that uncouples mitochondrial electron transport. However, the innate transcription factors that enable the rapid adaptive response of BAT are unclear. Here, we identify estrogen-related receptor gamma (ERRg) as a critical factor for maintaining BAT identity. ERRg is selectively expressed in BAT versus WAT, in which, in the absence of PGC1a, it drives a signature transcriptional network of thermogenic and oxidative genes in the basal (i.e., thermoneutral) state. Mice lacking ERRg in adipose tissue(ERRgKOmice) displaymarkeddownregulation of BAT-selective genes that leads to a pronounced whitening of BAT. Consistent with the transcriptional changes, the thermogenic capacity of ERRgKO mice is severely blunted, such that they fail to survive an acute cold challenge. These findings reveal a role for ERRg as a critical thermoneutral maintenance factor required to prime BAT for thermogenesis.

• 出版日期2018-3-13