Advantages of HILIC Mobile Phases for LC-ESI-MS-MS Analysis of Neurotransmitters

作者：Chirita Tampu Raluca Ioana^*; West Caroline; Fougere Laetitia; Elfakir Claire

来源：LC-GC Europe, 2013, 26(3): 128-+.

This article investigates the influence of liquid mobile phase composition on the response measured in electrospray ionization-mass spectrometry (ESI-MS) for 12 selected neurotransmitters. The aim was to find the optimal conditions to achieve sufficient limits of detection (LOD) that would permit their detection by liquid chromatography-tandem mass spectrometry (LC-MS-MS) in biological samples (brain extracts). The advantages of solvent-rich mobile phases typically used in hydrophilic interaction liquid chromatography (HILIC) are clear. The HILIC-ESI-MS-MS system optimized for the 12 selected compounds analysis presented significant advantages over other existing methods.

• 出版日期2013-3