A green organocatalyzed one-pot protocol for efficient synthesis of new substituted pyrimido[4,5-d]pyrimidinones using a Biginelli-like reaction

作者：Rimaz Mehdi; Khalafy Jabbar; Mousavi Hossein

来源：Research on Chemical Intermediates, 2016, 42(12): 8185-8200.

DOI：10.1007/s11164-016-2588-6

• Biginelli-like reaction
• Pyrimido[45-d]pyrimidine
• Arylgylyoxalmonohydrate
• Green chemistry
• One-pot

In this article, we have demonstrated a green and facile one-pot approach for the regio- and chemoselective synthesis of 5-aryloyl-1,3-dimethyl-7-thioxo-5,6,7,8-tetrahydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione derivatives in water at 50 A degrees C. This transformation presumably proceeds via a three-component tandem annulation of arylglyoxalmonohydrates with 1,3-dimethylbarbituric acid and thiourea in the presence of catalytic amounts of DABCO or l-proline, involving a Biginelli-like reaction.

• 出版日期2016-12