A chemo-enzymatic cascade for the one-pot synthesis of 1-deoxy-D-xylulose 5-phosphate and 1-deoxy-D-xylulose

作者：Dai, Shao-Bo; Liao, Juan; Tian, Jie; Li, Heng; Gao, Wen-Yun^*

来源：Tetrahedron Letters, 2012, 53(36): 4809-4812.

DOI：10.1016/j.tetlet.2012.06.062

• 1-Deoxy-D-xylulose 5-phosphate
• 1-Deoxy-D-xylulose
• Chemo-enzymatic cascade
• Methylerythritol phosphate pathway

A chemo-enzymatic cascade for the one-pot preparation of 1-deoxy-D-xylulose 5-phosphate (DXP) and 1-deoxy-D-xylulose (DX) from stable, cheap, and easily available starting material R-glycidol is reported. The epoxide ring of R-glycidol was opened with phosphate to generate L-glycerol 3-phosphate, which was subsequently converted into the target molecules by combination of multi-enzymatic reactions in the same flask with purified overall yields of 27.6% (DXP) and 33% (DX), respectively. This approach represents the first one-pot chemo-enzymatic synthesis of these two biologically important compounds.

• 出版日期2012-9-5
• 单位西北大学