Decreased expression of let-7f associates with the poor prognosis of glioma patients

作者：Zhu, Jianxin; Xiao, Yilei; Li, Li; Fang, Baojun; Yu, Fuhua; Zhang, Shubao; Sun, Ming; Zhao, Qingju; Li, Gang^*

来源：International Journal of Clinical and Experimental Pathology, 2016, 9(9): 9443-9448.

• Let-7f
• glioma
• prognosis

Objectives: Let-7f has been reported to play regulatory roles in several types of cancer and could act as a prognostic biomarker for cancer patients. The purpose of this study was to evaluate the prognostic value of let-7f in glioma patients. Methods: The relative expression levels of let-7f in tumor tissues and corresponding normal tissues of 108 glioma patients were detected by qRT-PCR. Chi-square test was used for analyzing the association between the expression level of let-7f and the clinical features. Besides, Kaplan-Meier method was performed to estimate the overall survival of glioma patients. The prognostic significance of let-7f was evaluated by Cox regression analysis. Results: The relative expression level of let-7f in tumor tissues was lower than in normal tissues (0.45 vs 1.09). Chi-square test indicated that let-7f expression was associated with tumor size (P=0.004) and WHO grade (P=0.000). The results of Kaplan-Meier method suggested that patients with low expression level of let-7f had shorter overall survival time than those with high expression level (24.1 months vs 34.5 months, log rank test, P=0.000). Moreover, let-7f could act as an independent biomarker for glioma prognosis (HR=1.971, 95% CI=1.381-2.813, P=0.000). Conclusion: The decreased expression of let-7f is detected in glioma tissues and the expression levels are associated with tumor progression. Let-7f may be a potential indicator for prognosis of glioma patients.

• 出版日期2016
• 单位山东大学; 聊城市人民医院