An expeditious one-pot synthesis of diethyl N-Boc-1-aminoalkylphosphonates

作者：Klepacz A; Zwierzak A^*

来源：Tetrahedron Letters, 2002, 43(6): 1079-1080.

DOI：10.1016/S0040-4039(01)02289-4

• alpha-amidoalkyl-p-tolyl sulfones
• N-Boc imines
• diethyl phosphite

A general one-pot, purification-free synthesis of diethyl N-Boc-1-aminoalkylphosphonates has been developed. The procedure involves base-catalyzed Michael-type addition of sodium diethyl phosphite to N-Boc imines generated in situ by the action of sodium hydride on alpha-amidoalkyl-p-tolyl sulfones in tetrahydrofuran.

• 出版日期2002-2-4