A Fatal Case of JC Virus Meningitis Presenting with Hydrocephalus in a Human Immunodeficiency Virus-Seronegative Patient

作者：Agnihotri Shruti P; Wuthrich Christian; Dang Xin; Nauen David; Karimi Reza; Viscidi Raphael; Bord Evelyn; Batson Stephanie; Troncoso Juan; Koralnik Igor J^*

来源：Annals of Neurology, 2014, 76(1): 140-147.

DOI：10.1002/ana.24192

JC virus (JCV) is the etiologic agent of progressive multifocal leukoencephalopathy, JCV granule cell neuronopathy, and JCV encephalopathy. Whether JCV can also cause meningitis has not yet been demonstrated. We report a case of aseptic meningitis resulting in symptomatic hydrocephalus in a human immunodeficiency virus-seronegative patient. Brain imaging showed enlargement of ventricles but no parenchymal lesion. She had a very high JC viral load in the cerebrospinal fluid (CSF) and developed progressive cognitive dysfunction despite ventricular drainage. She was diagnosed with pancytopenia and passed away after 5.5 months. Postmortem examination revealed productive JCV infection of leptomeningeal and choroid plexus cells, and limited parenchymal involvement. Sequencing of JCV CSF strain showed an archetype-like regulatory region. Further studies of the role of JCV in aseptic meningitis and in idiopathic hydrocephalus are warranted.

• 出版日期2014-7