Muller cells upregulate the expression of SAP97 in light-injured rat retina

作者：Ren, Hui; Xu, Gezhi^*; Qian, Jiang; Zhou, Min; Gonzales, John; Ni, Yingqin

来源：NeuroReport, 2010, 21(12): 832-836.

DOI：10.1097/WNR.0b013e32833d40ab

• aquaporin
• blue light injury
• Kir4.1
• Muller cell
• outer retinal edema
• SAP97

SAP97 is thought to play key roles in synapse assembly and synaptic plasticity. This study was carried out to determine whether it is involved in the Muller cell response to blue light injury. In light-injured rats, obvious intracellular edema in the outer retina was observed by transmission electron microscopy. The immunostaining of SAP97 was upregulated and concentrated in the Muller cell processes after photic injury, which was similar to the changes of AQP4 and the inwardly rectifying potassium channel, Kir4.1. Western blots showed that SAP97 and AQP4 protein levels were both increased on the third day after light exposure when compared with the control group (P<0.05). The upregulation of SAP97 coincides with the redistribution of AQP4 and Kir4.1 in blue light-injured rat retina.

• 出版日期2010-8-23
• 单位复旦大学