MERP1: a mammalian ependymin-related protein gene differentially expressed in hematopoietic cells

作者：Gregorio King CC^*; McLeod JL; Collier FML; Collier GR; Bolton KA; Van Der Meer GJV; Apostolopoulos J; Kirkland MA

来源：Gene, 2002, 286(2): 249-257.

DOI：10.1016/S0378-1119(02)00434-1

• bone marrow
• umbilical cord blood
• CD34(+)
• protocadherin

We have utilized differential display polymerase chain reaction to investigate the gene expression of hematopoietic progenitor cells from adult bone marrow and umbilical cord blood. A differentially expressed gene was identified in CD34(+) hematopoietic progenitor cells, with low expression in CD34(-) cells. We have obtained the full coding sequence of this gene which we designated human mammalian ependymin-related protein 1 (MERP1). Expression of MERP1 was found in a variety of normal human tissues. and is 4- and 10-fold higher in adult bone marrow and umbilical cord blood CD34- cells, respectively, compared to CD34(-) cells, Additionally, MERP1 expression in a hematopoietic stem cell enriched population was down-regulated with proliferation and differentiation. Conceptual translation of the MERP1 open reading frame reveals significant homology to two families of glycoprotein calcium-dependant cell adhesion molecules: ependymins and proto-cadherins.

• 出版日期2002-3-20
• 单位迪肯大学