Dancing with chemical formulae of antivirals: A personal account

作者：De Clercq Erik^*

来源：Biochemical Pharmacology, 2013, 86(6): 711-725.

DOI：10.1016/j.bcp.2013.07.012

• Valaciclovir
• Bromovinyldeoxyuridine
• 2 ',3 '-Dideoxynucleoside (ddN) analogues
• Acyclic nucleoside phosphonates
• Tenofovir disoproxil fumarate (TDF)
• Tenofovir alafenamide (GS-7340)
• GS-9191, GS-9219, cPrPMEDAP and PMEG
• O-DAPy and 5-azaC phosphonate analogues
• HEPT and TIBO derivatives
• Bicyclam (AMD3100) derivatives

A chemical structure is a joy forever, and this is how I perceived the chemical structures of a number of antiviral compounds with which I have been personally acquainted over the past 3 decades: (1) amino acid esters of acyclovir (i.e. valaciclovir); (2) 5-substituted 2'-deoxyuridines (i.e. brivudin); (3) 2',3'-dideoxynucleoside analogues (i.e. stavudine); (4) acyclic nucleoside phosphonates (ANPs) (i.e. cidofovir, adefovir); (5) tenofovir disoproxil fumarate (TDF) and drug combinations therewith; (6) tenofovir alafenamide (TAF, GS-7340), a new phosphonoamidate prodrug of tenofovir; (7) pro-prodrugs of PMEG (i.e. GS-9191 and GS-9219); (8) new ANPs: O-DAPy and 5-aza-C phosphonates; (9) non-nucleoside reverse transcriptase inhibitors (NNRTIs): HEPT and TIBO derivatives; and (10) bicyclam derivatives (i.e. AMD3100).

• 出版日期2013-9-15
• 单位河北医科大学