Association of myeloperoxidase with total and cardiovascular mortality in individuals undergoing coronary angiography-The LURIC study

作者：Scharnagl Hubert; Kleber Marcus E; Genser Bernd; Kickmaier Sandra; Renner Wilfried; Weihrauch Gisela; Grammer Tanja; Rossmann Christine; Winkelmann Bernhard R; Boehm Bernhard O; Sattler Wolfgang; Maerz Winfried; Malle Ernst^*

来源：International Journal of Cardiology, 2014, 174(1): 96-105.

DOI：10.1016/j.ijcard.2014.03.168

• Myeloperoxidase
• Inflammation
• High-density lipoprotein
• Cardiovascular mortality
• Risk factor

Background: The phagocytic enzyme myeloperoxidase (MPO) acts as a front-line defender against microorganisms. However, increased MPO levels have been found to be associated with complex and calcified atherosclerotic lesions and incident cardiovascular disease. Therefore, this study aimed to investigate a predictive role of MPO, a biomarker of inflammation and oxidative stress, for total and cardiovascular mortality in patients referred to coronary angiography. %26lt;br%26gt;Methods and results: MPO plasma concentrations along with eight MPO polymorphisms were determined in 3036 participants of the Ludwigshafen Risk and Cardiovascular Health study (median follow-up 7.75 years). MPO concentrations were positively associated with age, diabetes, smoking, markers of systemic inflammation (interleukin-6, fibrinogen, C-reactive protein, serum amyloid A) and vascular damage (vascular cellular adhesion molecule-1 and intercellular adhesion molecule-1) but negatively associated with HDL-cholesterol and apolipoprotein A-I. After adjustment for cardiovascular risk factors MPO concentrations in the highest versus the lowest quartile were associated with a 1.34-fold risk (95% CI: 1.09-1.67) for total mortality. In the adjusted model the hazard ratio for cardiovascular mortality in the highest MPO quartile was 1.42 (95% CI: 1.07-1.88). Five MPO polymorphisms were positively associated with MPO concentrations but not with mortality. Using Mendelian randomization, we did not obtain evidence for a causal association of MPO with either total or cardiovascular mortality. %26lt;br%26gt;Conclusions: MPO concentrations but not genetic variants at the MPO locus are independently associated with risk for total and cardiovascular mortality in coronary artery disease patients.

• 出版日期2014-6-1
• 单位南阳理工学院; 河北医科大学