A new phenanthrene derivative and two diarylheptanoids from the roots of Brassica rapa ssp. campestris inhibit the growth of cancer cell lines and LDL-oxidation

作者：Wu Qian; Cho Jin Gyeong; Yoo Ki Hyun; Jeong Tae Sook; Park Ji Hae; Kim Su Yeon; Kang Ji Hyun; Chung In Sik; Choi Myung Sook; Lee Kyung Tae; Chung Hae Gon; Bang Myun Ho; Baek Nam In^*

来源：Archives of Pharmacal Research, 2013, 36(4): 423-429.

DOI：10.1007/s12272-013-0068-8

• Brassica rapa ssp campestris
• Brassicaphenanthrene A
• 6-Paradol
• trans-6-Shogaol
• HCT-116
• HeLa
• Low density lipoprotein
• MCF-7

Brassica rapa ssp. campestris (Brassicaceae) is a conical, deep purple, edible root vegetable commonly known as a turnip. We initiated phytochemical and pharmacological studies to search for biological active compounds from the roots of B. rapa ssp. campestris. We isolated a novel phenanthrene derivative, 6-methoxy-1-[10-methoxy-7-(3-methylbut-2-enyl)phenanthren-3-yl]undecane-2,4-dione, named brassicaphenanthrene A (3) along with two known diarylheptanoid compounds, 6-paradol (1) and trans-6-shogaol (2), through the repeated silica gel (SiO2), octadecyl silica gel, and Sephadex LH-20 column chromatography. The chemical structures of the compounds were determined by spectroscopic data analyses including nuclear magnetic resonance, mass spectrometry, ultraviolet spectroscopy, and infra-red spectroscopy. All compounds exhibited high inhibitory activity against the growth of human cancer lines, HCT-116, MCF-7, and HeLa, with IC50 values ranging from 15.0 to 35.0 mu M and against LDL-oxidation with IC50 values ranging from 2.9 to 7.1 mu M.

• 出版日期2013-4