Acute HCV/HIV Coinfection Is Associated with Cognitive Dysfunction and Cerebral Metabolite Disturbance, but Not Increased Microglial Cell Activation

作者：Garvey Lucy J^*; Pavese Nicola; Ramlackhansingh Anil; Thomson Emma; Allsop Joanna M; Politis Marios; Kulasegaram Ranjababu; Main Janice; Brooks David J; Taylor Robinson Simon D; Winston Alan

来源：PLos One, 2012, 7(7): e38980.

DOI：10.1371/journal.pone.0038980

Background: Microglial cell activation and cerebral function impairment are described in both chronic hepatitis C viral (HCV) and Human-Immune-Deficiency viral (HIV) infections. The aim of this study was to investigate the effect of acute HCV infection upon cerebral function and microglial cell activation in HIV-infected individuals.
Methods: A case-control study was conducted. Subjects with acute HCV and chronic HIV coinfection (aHCV) were compared to matched controls with chronic HIV monoinfection (HIVmono). aHCV was defined as a new positive plasma HCV RNA within 12 months of a negative RNA test. Subjects underwent neuro-cognitive testing (NCT), cerebral proton magnetic resonance spectroscopy (H-1-MRS) and positron emission tomography (PET) using a C-11-radiolabeled ligand (PK11195), which is highly specific for translocator protein 18 kDA receptors on activated microglial cells. Differences between cases and controls were assessed using linear regression modelling.
Results: Twenty-four aHCV cases completed NCT and H-1-MRS, 8 underwent PET. Of 57 HIVmono controls completing NCT, 12 underwent H-1-MRS and 8 PET. Subjects with aHCV demonstrated on NCT, significantly poorer executive mean (SD) error rate 26.50(17.87) versus 19.09(8.12), p = 0.001) and on H-1-MRS increased myo-inositol/ creatine ratios (mI/Cr, a marker of cerebral inflammation) in the basal ganglia (ratio of 0.71(0.22) versus 0.55(0.23), p = 0.03), compared to subjects with HIVmono. On PET imaging, no difference in C-11-PK11195 binding potential (BP) was observed between study groups (p > 0.10 all cerebral locations), however lower BPs were associated with combination antiretroviral therapy (cART) use in the parietal (p = 0.01) and frontal (p = 0.03) cerebral locations.
Discussion: Poorer cognitive performance and disturbance of cerebral metabolites are observed in subjects with aHC, V compared to subjects with HIVmono. Higher C-11-PK11195 BP was not observed in subjects with aHCV, but was observed in subjects not on cART.

• 出版日期2012-7-12