alpha-Mangostin from Garcinia mangostana Linn: An updated review of its pharmacological properties

作者：Ibrahim Mohamed Yousif; Hashim Najihah Mohd; Mariod Abdalbasit Adam^*; Mohan Syam; Abdulla Mahmood Ameen; Abdelwahab Siddig Ibrahim; Arbab Ismail Adam

来源：Arabian Journal of Chemistry, 2016, 9(3): 317-329.

DOI：10.1016/j.arabjc.2014.02.011

• alpha-Mangostin
• Garcinia mangostana Linn
• Pharmacological properties

Over the past decades, various studies have highlighted the pure natural compound, alpha-mangostin as their main topic. The compound's pre-clinical and pharmacological properties have been recognized and defined in these studies. alpha-Mangostin shows strong pharmacological effects in in vitro and in vivo model systems by targeting a number of vital cellular factors through various mechanisms of action. Despite its important molecular versatility, the alpha-mangostin still has limited clinical application. In order to optimize the conditions of this compound as a chemotherapeutic and chemopreventive agent, for instance in diseases such as cancer, obesity, diabetes as well as inflammatory disorders, the recent tendency is to limit the range of its pharmacological properties. The present work reviews recent studies on the central and potential pharmacological principles as well as the preclinical applications of the alpha-mangostin.

• 出版日期2016-5