A dedicated neonatal brain imaging system

作者：Hughes Emer J^*; Winchman Tobias; Padormo Francesco; Teixeira Rui; Wurie Julia; Sharma Maryanne; Fox Matthew; Hutter Jana; Cordero Grande Lucilio; Price Anthony N; Allsop Joanna; Bueno Conde Jose; Tusor Nora; Arichi Tomoki; Edwards A D; Rutherford Mary A; Counsell Serena J; Hajnal Joseph V

来源：Magnetic Resonance in Medicine, 2017, 78(2): 794-804.

DOI：10.1002/mrm.26462

• neonatal
• brain
• head coil
• unsedated

PurposeThe goal of the Developing Human Connectome Project is to acquire MRI in 1000 neonates to create a dynamic map of human brain connectivity during early development. High-quality imaging in this cohort without sedation presents a number of technical and practical challenges.
MethodsWe designed a neonatal brain imaging system (NBIS) consisting of a dedicated 32-channel receive array coil and a positioning device that allows placement of the infant's head deep into the coil for maximum signal-to-noise ratio (SNR). Disturbance to the infant was minimized by using an MRI-compatible trolley to prepare and transport the infant and by employing a slow ramp-up and continuation of gradient noise during scanning. Scan repeats were minimized by using a restart capability for diffusion MRI and retrospective motion correction. We measured the 1) SNR gain, 2) number of infants with a completed scan protocol, and 3) number of anatomical images with no motion artifact using NBIS compared with using an adult 32-channel head coil.
ResultsThe NBIS has 2.4 times the SNR of the adult coil and 90% protocol completion rate.
ConclusionThe NBIS allows advanced neonatal brain imaging techniques to be employed in neonatal brain imaging with high protocol completion rates. Magn Reson Med 78:794-804, 2017. (c) 2016 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

• 出版日期2017-8