Neuroprotective Effects of Agmatine in Experimental Peripheral Nerve Injury in Rats: A Prospective Randomized and Placebo-Controlled Trial

作者：Sezer Aykut; Guclu Bulent^*; Kazanci Burak; Cakir Murteza; Coban Mustafa Kemal

来源：Turkish Neurosurgery, 2014, 24(2): 196-201.

DOI：10.5137/1019-5149.JTN.7324-12.1

• Agmatine
• Axonotmesis
• Neurotmesis
• Peripheral nerve injury
• Rat

AIM: The purpose of this study was to demonstrate the activity of agmatine, an inducible nitric oxide synthase (iNOS) inhibitor and selective N-methyl-D-aspartate receptor (NMDAR) antagonist, on reducing tissue damage in distal part of traumatic nerve in an experimental rat peripheral nerve injury model.
MATERIAL and METHODS: Sciatic nerves of 30 Sprague Dawley male rats were used. Rats were divided into 5 groups; group 1 (n=6), control group; group 2 (n=6), axonotmesis + placebo group; group 3 (n=6), axonotmesis + 50 mg/kg agmatine treatment group; group 4 (n=6), neurotmesis + placebo group; group 5 (n=6), neurotmesis + 50 mg/kg agmatine treatment group. Axonolysis, axon degeneration, edema, hemorrhage, and inflammation were evaluated in histopathologic examinations of all the groups.
RESULTS: When group 2 was compared with group 3 in histopathologic sections, axonolysis was less in group 3 (p=0.007), as was axon degeneration (p=0.022) and edema (p=0.018). When group 4 was compared with group 5, axonolysis was less in group 5 (p=0.009), as was axon degeneration (p=0.006) and edema (p=0.021).
CONCLUSION: This study demonstrated agmatine to have antioxidant and antineurotoxic effects in an experimental rat peripheral nerve injury model.

• 出版日期2014-3