Probiotics in neonatology

作者：Hickey Leah^*; Jacobs Susan E; Garland Suzanne M

来源：Journal of Paediatrics and Child Health, 2012, 48(9): 777-783.

DOI：10.1111/j.1440-1754.2012.02508.x

• necrotising enterocolitis
• neonatology
• preterm
• term infant
• probiotics
• sepsis

Probiotics are micro-organisms that confer health benefits on the host. Postulated mechanisms include: increasing resistance of the mucosal barrier to migration of bacteria and their toxins by strengthening intestinal cell junctions, modification of host response to microbial products, augmentation of immunoglobulin A mucosal responses, enhancement of enteral nutrition to inhibit the growth of pathogens; production of antimicrobial proteins; and competitive exclusion of potential pathogens. Published meta-analyses and systematic reviews report the effects of probiotics on important clinical outcomes in neonates. This paper will review the evidence for probiotic supplementation in neonatology, with a focus on preterm infants.

• 出版日期2012-9