Adrenergic beta 2 Receptor Activation Stimulates Anti-Inflammatory Properties of Dendritic Cells In Vitro

作者：Nijhuis Laurens E; Olivier Brenda J; Dhawan Shobit; Hilbers Francisca W; Boon Louis; Wolkers Monika C; Samsom Janneke N; de Jonge Wouter J^*

来源：PLos One, 2014, 9(1): e85086.

DOI：10.1371/journal.pone.0085086

Vagal nerve efferent activation has been shown to ameliorate the course of many inflammatory disease states. This neuro-modulatory effect has been suggested to rest on acetylcholine receptor (AChR) activation on tissue macrophages or dendritic cells (DCs). In more recent studies, vagal anti-inflammatory activity was shown involve adrenergic, splenic, pathways. Here we provide evidence that the adrenergic, rather than cholinergic, receptor activation on bone marrow derived DCs results in enhanced endocytosis uptake, enhanced IL-10 production but a decreased IL-6, IL-12p70 and IL-23 production. In antigen specific T cell stimulation assays, adrenergic beta 2 receptor activation on bone marrow DCs led to an enhanced potential to induce Foxp3 positive suppressive Treg cells. These effects were independent of IL10-R activation, TGF beta release, or retinoic acid (RA) secretion. Hence, adrenergic receptor b2 activation modulates DC function resulting in skewing towards anti-inflammatory T cell phenotypes.

• 出版日期2014-1-22