Age, plasticity, and homeostasis in childhood brain disorders

作者：Dennis Maureen^*; Spiegler Brenda J; Juranek Jenifer J; Bigler Erin D; Snead O Carter; Fletcher Jack M

来源：Neuroscience and Biobehavioral Reviews, 2013, 37(10): 2760-2773.

DOI：10.1016/j.neubiorev.2013.09.010

• Plasticity
• Homeostasis
• Neurodevelopmental disorders
• Childhood-acquired brain damage
• Age at brain injury
• Time since brain injury

It has been widely accepted that the younger the age and/or immaturity of the organism, the greater the brain plasticity, the young age plasticity privilege. This paper examines the relation of a young age to plasticity, reviewing human pediatric brain disorders, as well as selected animal models, human developmental and adult brain disorder studies. As well, we review developmental and childhood acquired disorders that involve a failure of regulatory homeostasis. Our core arguments are as follows: %26lt;br%26gt;- Plasticity is neutral with respect to outcome. Although the effects of plasticity are often beneficial, the outcome of plasticity may be adaptive or maladaptive. %26lt;br%26gt;- The young age plasticity privilege has been overstated. %26lt;br%26gt;- Plastic change operates in concert with homeostatic mechanisms regulating change at every point in the lifespan. %26lt;br%26gt;- The same mechanisms that propel developmental change expose the immature brain to adverse events, making it more difficult for the immature than for the mature brain to sustain equilibrium between plasticity and homeostasis. %26lt;br%26gt;- Poor outcome in many neurodevelopmental disorders and childhood acquired brain insults is related to disequilibrium between plasticity and homeostasis.

• 出版日期2013-12