Design, Synthesis and Anti-HIV Integrase Evaluation of N-(5-Chloro-8-Hydroxy-2-Styrylquinolin-7-yl)Benzenesulfonamide Derivatives

作者：Jiao Zi Guo; He Hong Qiu; Zeng Cheng Chu^*; Tan Jian Jun; Hu Li Ming; Wang Cun Xin

来源：Molecules, 2010, 15(3): 1903-1917.

DOI：10.3390/molecules15031903

• styrylquinoline derivatives
• HIV-1 IN inhibitors
• N-(styryl-8-hydroxyquinolin-7-yl)-benzenesulfonamide derivatives

Styrylquinoline derivatives are demonstrated to be HIV-1 integrase inhibitors. On the basis of our previous CoMFA analysis of a series of styrylquinoline derivatives, N[(2-substituted-styryl)-5-chloro-8-hydroxyquinolin-7-yl]-benzenesulfona mide derivatives were designed and synthesized, and their possible HIV IN inhibitory activity was evaluated.

• 出版日期2010-3
• 单位北京工业大学