Antibody- and aptamer-strategies for GvHD prevention

作者：Oelkrug Christopher^*; Sack Ulrich; Boldt Andreas; Nascimento Isis C; Ulrich Henning; Fricke Stephan

来源：JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2015, 19(1): 11-20.

DOI：10.1111/jcmm.12416

• antibody
• aptamer
• GvHD
• GvL
• murine model
• transplantation

Prevention of Graft-versus-Host-Disease (GvHD) by preserved Graft-versus-Leukaemia (GvL) effect is one of the major obstacles following allogeneic haematopoietic stem cell transplantation. Currently used drugs are associated with side effects and were not able to separate GvHD from the GvL-effect because of general T-cell suppression. This review focuses on murine models for GvHD and currently available treatment options involving antibodies and applications for the therapeutic use of aptamers as well as strategies for targeting immune responses by allogenic antigens.

• 出版日期2015-1