A Two-step Selection of Breast Cancer Patients Candidates for Exclusive IORT with Electrons: A Mono-institutional Experience

作者：Guenzi M^*; Fozza A; Timon G; Belgioia L; Vidano G; Cavagnetto F; Agostinelli S; Gusinu M; Carli F; Cafiero F; Friedman D; Canavese G; Corvo R

来源：Anticancer Research, 2012, 32(4): 1533-1536.

• Breast cancer
• intraoperative radiation therapy
• decision process

Aim: To assess the impact of a two-step multiparameter selection on the actual enrollment of women with breast cancer into a prospective intraoperative radiotherapy (IORT) trial. Patients and Methods: From September 2009, a prospective clinical trial was started in order to deliver adjuvant exclusive single -fraction IORT to patients with early breast cancer. To select patients meeting suitable eligibility criteria for the clinical trial, a two-step decision process was developed: at pre-surgical examination (first step) and during surgery (second step). Results: A series of 464 patients with breast cancer was analysed: at the first step, out of 464 patients, 333 (71%) were considered eligible for the IORT protocol; at the second step, out of 333 patients, 199 (60%) met the eligibility criteria and received the IORT fraction according to the criteria of the controlled trial. Conclusion: In our experience, the ultimate rate of patients who enrolled in the IORT clinical trial after the two-step decision process was 43%.

• 出版日期2012-4