A survey of schistosome protein domain types: Insights into unique biological properties

作者：Hughes Austin L^*; Friedman Robert

来源：Molecular and Biochemical Parasitology, 2011, 177(2): 100-105.

DOI：10.1016/j.molbiopara.2011.02.001

• DyP-type peroxidase
• Densovirus NS1 domain
• Schistosoma mansoni
• Schistosoma japonicum
• Schistosome genome

Using the PROSITE database and search tools, we conducted a comprehensive bioinformatic analysis of the predicted protein sequences of the flatworm parasites Schistosoma mansoni and Schistosoma japonicum and seven other animal genomes in order to identify novel schistosome-specific features. Our analyses revealed a relative paucity of proline-rich domains in schistosomes in comparison with their human host and a corresponding enrichment in schistosomes of asparagine-rich, serine-rich, and threonine-rich domains. Domain types found in both schistosome species but not in human included the two-component system sensor histidine kinase/response regulator; C83 family peptidase; DyP-type peroxidase; and densovirus NS1-type domain. Unique features of the schistosome proteome may help guide development of new drugs, while the presence of a densovirus-derived protein in S. mansoni suggests that this species may be infected by a virus of this group, which might be useful as a biological control agent.

• 出版日期2011-6