X Chromosome Inactivation and Autoimmunity

作者：Brooks Wesley H^*

来源：Clinical Reviews in Allergy and Immunology, 2010, 39(1): 20-29.

DOI：10.1007/s12016-009-8167-5

• X chromosome
• X inactivation
• Autoimmunity
• Polyamines

Autoimmune diseases appear to have multiple contributing factors including genetics, epigenetics, environmental factors, and aging. The predominance of females among patients with autoimmune diseases suggests possible involvement of the X chromosome and X chromosome inactivation. X chromosome inactivation is an epigenetic event resulting in multiple levels of control for modulation of the expression of X-linked genes in normal female cells such that there remains only one active X chromosome in the cell. The extent of this control is unique among the chromosomes and has the potential for problems when regulation is disrupted. Here we discuss the X chromosome inactivation process and how the X chromosome and X chromosome inactivation may be involved in development of autoimmune disorders.

• 出版日期2010-8