A general protocol for the efficient synthesis of polyarylated benzenes by multiple Suzuki-Miyaura reactions of polychlorinated benzenes

作者：Reimann Sebastian; Ehlers Peter; Sharif Muhammad; Spannenberg Anke; Langer Peter^*

来源：Tetrahedron, 2016, 72(8): 1083-1094.

DOI：10.1016/j.tet.2016.01.010

• Catalysis
• Palladium
• Cross-coupling
• Arenes
• Chlorine
• Suzuki reaction

A general protocol for the highly efficient synthesis of polyarylated benzene derivatives by multiple Suzuki-Miyaura reactions of polychlorinated benzenes was developed. Using bulky and electron-rich phosphine ligands, up to quantitative yields of the desired compounds were achieved. Moreover, the reactions show good functional group tolerance and allow the employment of sterically demanding boronic acids.

• 出版日期2016-2-25