Protein Iodination by Click Chemistry

作者：Dong Shouliang; Moroder Luis; Budisa Nediljko^*

来源：ChemBioChem, 2009, 10(7): 1149-1151.

DOI：10.1002/cbic.200800816

• click chemistry
• cycloadditions
• homopropargylglycine
• methionine
• protein modifications

<jats:title>Abstract</jats:title><jats:p><jats:bold>Two steps to click iodine</jats:bold>: We have developed a two‐step reaction for protein iodination using click chemistry. With this method, which is summarized in the scheme, covalent attachment of a stable iodine‐containing aromatic azide moiety to an alkyne‐containing protein was achieved.<jats:boxed-text content-type="graphic" position="anchor"><jats:graphic xmlns:xlink="http://www.w3.org/1999/xlink" mimetype="image/gif" position="anchor" specific-use="enlarged-web-image" xlink:href="graphic/mcontent.gif"><jats:alt-text>magnified image</jats:alt-text></jats:graphic></jats:boxed-text></jats:p>

• 出版日期2009-5-4