A sensitive BODIPY-based fluorescent probe suitable for hypochlorite detection in living cells

作者：Li, Yuanyuan; Tang, Yong; Gao, Mengmeng; Wang, Yun^*; Han, Juan; Xia, Jinchen; Wang, Lei; Tang, Xu; Ni, Liang

来源：Journal of Photochemistry and Photobiology A: Chemistry , 2018, 352: 65-72.

DOI：10.1016/j.jphotochem.2017.10.037

• Fluorescent probe
• Hypochlorite
• BODIPY
• Bioimaging

A fluorescent probe composed of BODIPY and 2,4-dinitrophenylhydrazine was designed for the detection of CIO-. The oxidizing reaction between probe and CIO- resulted in a distinct fluorescence enhancement together with a color variation from pink to orange. This probe showed excellent selectivity to CIO- among various ions including common reactive oxygen species and high sensitivity with a detection limit of 228 nM. A fast response (7 min) was observed, which made the probe a promising method in real-time detection. Furthermore, this probe was successfully applied to monitor CIO- in real-life water and living cells.

• 出版日期2018-2-1
• 单位江苏大学