Antibacterial properties of laser spinning glass nanofibers

作者：Echezarreta Lopez M M^*; De Miguel T; Quintero F; Pou J; Landin M

来源：International Journal of Pharmaceutics, 2014, 477(1-2): 113-121.

DOI：10.1016/j.ijpharm.2014.09.050

• Bioactive glasses
• Bioinert glasses
• Biocompatibility
• Antibacterial properties
• Nanofibers
• Laser spinning
• Dynamic conditions

A laser-spinning technique has been used to produce amorphous, dense and flexible glass nanofibers of two different compositions with potential utility as reinforcement materials in composites, fillers in bone defects or scaffolds (3D structures) for tissue engineering. Morphological and microstructural analyses have been carried out using SEM-EDX, ATR-FTIR and TEM. Bioactivity studies allow the nanofibers with high proportion in SiO2 (S18/12) to be classified as a bioinert glass and the nanofibers with high proportion of calcium (ICIE16) as a bioactive glass. The cell viability tests (MTT) show high biocompatibility of the laser spinning glass nanofibers. Results from the antibacterial activity study carried out using dynamic conditions revealed that the bioactive glass nanofibers show a dose-dependent bactericidal effect on Sthaphylococcus aureus (S. aureus) while the bioinert glass nanofibers show a bacteriostatic effect also dose-dependent. The antibacterial activity has been related to the release of alkaline ions, the increase of pH of the medium and also the formation of needle-like aggregates of calcium phosphate at the surface of the bioactive glass nanofibers which act as a physical mechanism against bacteria. %26lt;br%26gt;The antibacterial properties give an additional value to the laser-spinning glass nanofibers for different biomedical applications, such as treating or preventing surgery-associated infections.

• 出版日期2014-12-30