New Photosensitiser 5-ALA-GNPs for Photodynamic Therapy and Its Spectral Analysis

作者：Yao Cui ping; Wang Si jia; Yang Yang; Han Yu long; Xu Hao; Zeng Wei hui; Zhang Zhen xi^*

来源：Spectroscopy and Spectral Analysis, 2012, 32(9): 2519-2522.

DOI：10.3964/j.issn.1000-0593(2012)09-2519-04

• 5-ALA
• Gold nanoparticles
• Photodynamic therapy

A novel strategy by means of poly diallyl dimethylammonium chloride (PDDA) was used to make highly mono-dispersed positively charged gold nanoparticles, and 5-ALA was immobilized onto the gold nanoparticles through electrostatic interaction. The conjugation of 5-aminolevulinic acid (5-ALA) and gold nanopartilces were characterized by the integrated tools of resonance Rayleigh scattering (RRS), UV-Vis absorption spectra, transmission electron microscopy (TEM) and laser light scattering. The results demonstrated that 5-ALA can be attached onto positively charged gold nanoparticles. This new photosensitizer is significant for enhancing PDT efficacy clinically.

• 出版日期2012-9
• 单位西安交通大学