It's a knockout: CCN3 suppresses neointimal thickening

作者:Leask Andrew*
来源:Journal of Cell Communication and Signaling, 2010, 4(2): 109-110.
DOI:10.1007/s12079-010-0086-y

摘要

The role of CCN proteins in vivo is only just becoming understood. A prototypical member of the CCN family, CCN3 suppresses proliferation. In a study in press, Shimoyama and colleagues show that mice lacking CCN3 have a hyperproliferative response to vascular injury. These data, along with other recent observations, suggest that CCN3 may represent a novel therapy for hyperproliferative diseases.

  • 出版日期2010-6

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