科研之友
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摘要
Among the research of new pharmaceutic dosage forms, controlled-release drug delivery system is a very important issue nowdays. In this field, processes using supercritical fluid technology are mostly "clean" process leading to "clean" products. Meanwhile, inorganic porous materials are emerging as a new category of host/guest systems due to some interesting features such as their biological stability and their drug-releasing properties. This review summarizes the applications of supercritical fluid transport technology in preparation of controlled-release drug delivery system in recent years and pays more attention on the method using supercritical fluid as the solvent and inorganic mesoporous materials as the support to prepare this controlled-release drug delivery system. The technical principle, development of technological process and the main influence factors are discussed here besides the drug release experiments and the comparison with the traditional methods. It shows clearly the advantages and disadvantages of various processes, and sums up the superiority of the supercritical transport technology in preparing controlled-release drug delivery system. Although this technique has lots of advantages, as for the papers delivered at present, the research on supercritical fluid transport technology is just at its initial stage of development because there are so many factors influencing the experimental results and these factors are sometimes link-coupled. It is still challenging to make the preparation controllable. It indicates that the diffusion and penetration of the supercritical carbon dioxide drug solution in porous materials, the surface chemical and physical adsorption mechanism should be focused on as well as the controlled drug release mechanism, thermodynamic model and process dynamic.
- 出版日期2011-8-24
- 单位大连理工大学
