A recyclable copper catalysis in modified Friedlander quinoline synthesis

作者：Cho Chan Sik^*; Ren Wen Xiu; Yoon Nam Sik

来源：Journal of Molecular Catalysis A: Chemical , 2009, 299(1-2): 117-120.

DOI：10.1016/j.molcata.2008.10.024

• 2-Aminobenzyl alcohol
• Recyclable copper catalyst
• MS 4A
• Quinolines
• Ketones
• Cyclization

2-Aminobenzyl alcohol reacts with ketones in dioxane at 100 degrees C in the presence of a catalytic amount of a copper catalyst along with KOH and MS 4A under O(2) atmosphere to afford the corresponding quinolines in good yields. The catalytic system could be recovered and reused 10 times without any loss of catalytic activity. A similar catalytic System using copper catalyst/PEG-2000 is also effective for this coupling and cyclization with a similar catalytic potential. 2-Aminobenzyl alcohol is also coupled and cyclized with secondary alcohols Under the CuCl(2)/MS 4A catalytic system to give quinolines in moderate to good yields.

• 出版日期2009-2-18