LINGO1 Gene Analysis in Parkinson's Disease Phenotypes

作者：Lorenzo Betancor Oswaldo; Samaranch Lluis; Garcia Martin Elena; Cervantes Sebastian; Agundez Jose A G; Jimenez Jimenez Felix J; Alonso Navarro Hortensia; Luengo Antonio; Coria Francisco; Lorenzo Elena; Irigoyen Jaione; Pastor Pau^*

来源：Movement Disorders, 2011, 26(4): 722-727.

DOI：10.1002/mds.23452

• Parkinson's disease
• LINGO1
• essential tremor
• genetics
• association study

Background: Parkinson's disease (PD) and essential tremor (ET) may share some etiopathogenic factors. A genome-wide association study has shown that LINGO1 gene variants are associated with increased risk of ET. We hypothesized that LINGO1 variants could increase susceptibility to PD. Methods: A large series of PD subjects and healthy controls were genotyped for rs9652490 and rs11856808 LINGO1 single nucleotide polymorphisms (SNPs). Results: We found an increased frequency of the rs11856808(T/T) genotype in PD compared with controls (odds ratio = 1.46; corrected P value = 0.02). A recessive genetic model was the best fit for rs11856808 influence on PD (recessive gene action test: corrected P value = 0.01). Stratification analysis showed that rs11856808(T/T) genotype frequency was higher in the tremor-dominant PD and the classical PD (C-PD) subgroups (recessive gene action test for the C-PD subgroup: corrected P value = 0.004). Discussion: Our results indicate that LINGO1 variants could increase risk of PD, specifically those presenting the non-rigid-akinetic phenotypes, which suggests that LINGO1 may have a role in the etiology of tremor in PD at least in the Spanish population.

• 出版日期2011-3